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Rat Spastin (aa 1-581 )

Spg4 Swiss Prot#

B2RYN7

Spg4 Protein names

Spastin (EC 3.6.4.3)

Spg4 Gene names

Spast Spg4

Organism

Rattus norvegicus (Rat)

Spg4 Entry name

SPAST_RAT

Spg4 Codon optimized cDNA(gene) Clone

Spg4 Cat #

RPY1420

Tag

Spg4 contains A 6x histidine tag

Spg4 Formulation

Liquid

Spg4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Spg4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Spg4 Protein

Spg4 Cat #

PY1420

Spg4 Source

recombinant

Spg4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Spg4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Spg4 Activity

N/A

Tag

Spg4 Contains A 6x histidine tag

Spg4 Formulation

Liquid

Spg4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Spg4 family

AAA ATPase family, Spastin subfamily

Spg4 Subcellular locations

Membrane; Single-pass membrane protein. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm > cytoskeleton > spindle.

Spg4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis (By similarity). Plays a role in axon growth and the formation of axonal branches.

Spg4 Sequence

DDBJ

EMBL

GenBank

Spg4 3D structure

ModBase

Spg4 interaction

STRING

Spg4 Proteomic

PRIDE

Spg4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Spg4 Organism specific

CTD

MGI

Spg4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Spg4 Gene expression

Bgee

ArrayExpress

Genevestigator

Spg4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY