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| Human Suppressor cytokine signaling 7 (aa 1-581 ) |
| NAP4 Swiss Prot# | | O14512 |
| NAP4 Protein names | | Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4) |
| NAP4 Gene names | | SOCS7 NAP4 SOCS6 |
| Organism | | Homo sapiens (Human) |
| NAP4 Entry name | | SOCS7_HUMAN |
| NAP4 Codon optimized cDNA(gene) Clone |
| NAP4 Cat # | | RPY1419 |
| Tag | | NAP4 contains A 6x histidine tag |
| NAP4 Formulation | | Liquid |
| NAP4 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| NAP4 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant NAP4 Protein |
| NAP4 Cat # | | PY1419 |
| NAP4 Source | | recombinant |
| NAP4 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| NAP4 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| NAP4 Activity | | N/A |
| Tag | | NAP4 Contains A 6x histidine tag |
| NAP4 Formulation | | Liquid |
| NAP4 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant NAP4 Products | | For pricing and availability Click Here >>> |
| NAP4 family | | - |
| NAP4 Subcellular locations | | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. |
| NAP4 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
| NAP4 Sequence | | DDBJ | EMBL | GenBank |
| NAP4 3D structure | | ModBase |
| NAP4 interaction | | STRING |
| NAP4 Proteomic | | PRIDE |
| NAP4 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| NAP4 Organism specific | | CTD | MGI |
| NAP4 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| NAP4 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| NAP4 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |