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Human Frizzled-10 (aa 1-581 )

FZD10 Swiss Prot#

Q9ULW2

FZD10 Protein names

Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350)

FZD10 Gene names

FZD10

Organism

Homo sapiens (Human)

FZD10 Entry name

FZD10_HUMAN

FZD10 Codon optimized cDNA(gene) Clone

FZD10 Cat #

RPY1418

Tag

FZD10 contains A 6x histidine tag

FZD10 Formulation

Liquid

FZD10 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FZD10 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FZD10 Protein

FZD10 Cat #

PY1418

FZD10 Source

recombinant

FZD10 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FZD10 Purity

>90%, as determined by SDS-PAGE under reducing conditions

FZD10 Activity

N/A

Tag

FZD10 Contains A 6x histidine tag

FZD10 Formulation

Liquid

FZD10 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FZD10 family

G-protein coupled receptor Fz/Smo family

FZD10 Subcellular locations

Membrane; Multi-pass membrane protein.

FZD10 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

FZD10 Sequence

DDBJ

EMBL

GenBank

FZD10 3D structure

ModBase

FZD10 interaction

STRING

FZD10 Proteomic

PRIDE

FZD10 Genome annotation

Ensembl

GeneID

KEGG

UCSC

FZD10 Organism specific

CTD

MGI

FZD10 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FZD10 Gene expression

Bgee

ArrayExpress

Genevestigator

FZD10 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY