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Mouse Suppressor cytokine signaling 7 (aa 1-579 )

Cish7 Swiss Prot#

Q8VHQ2

Cish7 Protein names

Suppressor of cytokine signaling 7 (SOCS-7)

Cish7 Gene names

Socs7 Cish7 Nap4

Organism

Mus musculus (Mouse)

Cish7 Entry name

SOCS7_MOUSE

Cish7 Codon optimized cDNA(gene) Clone

Cish7 Cat #

RPY1413

Tag

Cish7 contains A 6x histidine tag

Cish7 Formulation

Liquid

Cish7 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cish7 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cish7 Protein

Cish7 Cat #

PY1413

Cish7 Source

recombinant

Cish7 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cish7 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cish7 Activity

N/A

Tag

Cish7 Contains A 6x histidine tag

Cish7 Formulation

Liquid

Cish7 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cish7 family

-

Cish7 Subcellular locations

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.

Cish7 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Cish7 Sequence

DDBJ

EMBL

GenBank

Cish7 3D structure

ModBase

Cish7 interaction

STRING

Cish7 Proteomic

PRIDE

Cish7 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cish7 Organism specific

CTD

MGI

Cish7 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cish7 Gene expression

Bgee

ArrayExpress

Genevestigator

Cish7 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY