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Human Podocalyxin (aa 1-558 )

PCLP Swiss Prot#

O00592

PCLP Protein names

Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)

PCLP Gene names

PODXL PCLP PCLP1

Organism

Homo sapiens (Human)

PCLP Entry name

PODXL_HUMAN

PCLP Codon optimized cDNA(gene) Clone

PCLP Cat #

RPY1351

Tag

PCLP contains A 6x histidine tag

PCLP Formulation

Liquid

PCLP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PCLP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PCLP Protein

PCLP Cat #

PY1351

PCLP Source

recombinant

PCLP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PCLP Purity

>90%, as determined by SDS-PAGE under reducing conditions

PCLP Activity

N/A

Tag

PCLP Contains A 6x histidine tag

PCLP Formulation

Liquid

PCLP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PCLP family

Podocalyxin family

PCLP Subcellular locations

Apical cell membrane. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > ruffle. Cell projection > microvillus. Membrane raft. Membrane; Single-pass type I membrane protein.

PCLP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

PCLP Sequence

DDBJ

EMBL

GenBank

PCLP 3D structure

ModBase

PCLP interaction

STRING

PCLP Proteomic

PRIDE

PCLP Genome annotation

Ensembl

GeneID

KEGG

UCSC

PCLP Organism specific

CTD

MGI

PCLP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PCLP Gene expression

Bgee

ArrayExpress

Genevestigator

PCLP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY