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Human Poly (aa 1-533 )

ADPRT3 Swiss Prot#

Q9Y6F1

ADPRT3 Protein names

Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)

ADPRT3 Gene names

PARP3 ADPRT3 ADPRTL3

Organism

Homo sapiens (Human)

ADPRT3 Entry name

PARP3_HUMAN

ADPRT3 Codon optimized cDNA(gene) Clone

ADPRT3 Cat #

RPY1294

Tag

ADPRT3 contains A 6x histidine tag

ADPRT3 Formulation

Liquid

ADPRT3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ADPRT3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ADPRT3 Protein

ADPRT3 Cat #

PY1294

ADPRT3 Source

recombinant

ADPRT3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ADPRT3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ADPRT3 Activity

N/A

Tag

ADPRT3 Contains A 6x histidine tag

ADPRT3 Formulation

Liquid

ADPRT3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ADPRT3 family

-

ADPRT3 Subcellular locations

Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > centrosome > centriole.

ADPRT3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

ADPRT3 Sequence

DDBJ

EMBL

GenBank

ADPRT3 3D structure

ModBase

ADPRT3 interaction

STRING

ADPRT3 Proteomic

PRIDE

ADPRT3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ADPRT3 Organism specific

CTD

MGI

ADPRT3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ADPRT3 Gene expression

Bgee

ArrayExpress

Genevestigator

ADPRT3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY