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| Human 5' exonuclease Apollo (aa 1-532 ) |
| SNM1B Swiss Prot# | | Q9H816 |
| SNM1B Protein names | | 5' exonuclease Apollo (EC 3.1.-.-) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B) |
| SNM1B Gene names | | DCLRE1B SNM1B |
| Organism | | Homo sapiens (Human) |
| SNM1B Entry name | | DCR1B_HUMAN |
| SNM1B Codon optimized cDNA(gene) Clone |
| SNM1B Cat # | | RPY1293 |
| Tag | | SNM1B contains A 6x histidine tag |
| SNM1B Formulation | | Liquid |
| SNM1B Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| SNM1B Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant SNM1B Protein |
| SNM1B Cat # | | PY1293 |
| SNM1B Source | | recombinant |
| SNM1B Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| SNM1B Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| SNM1B Activity | | N/A |
| Tag | | SNM1B Contains A 6x histidine tag |
| SNM1B Formulation | | Liquid |
| SNM1B Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant SNM1B Products | | For pricing and availability Click Here >>> |
| SNM1B family | | DNA repair metallo-beta-lactamase (DRMBL) family |
| SNM1B Subcellular locations | | Chromosome > telomere. Nucleus. Cytoplasm > cytoskeleton > centrosome. |
| SNM1B FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. |
| SNM1B Sequence | | DDBJ | EMBL | GenBank |
| SNM1B 3D structure | | ModBase |
| SNM1B interaction | | STRING |
| SNM1B Proteomic | | PRIDE |
| SNM1B Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| SNM1B Organism specific | | CTD | MGI |
| SNM1B Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| SNM1B Gene expression | | Bgee | ArrayExpress | Genevestigator |
| SNM1B Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
