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| Rat Na(+) H(+) exchange regulatory c actor NHE-RF3 (aa 1-523 ) |
| Clamp Swiss Prot# | | Q9JJ40 |
| Clamp Protein names | | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (C-terminal-linking and modulating protein) (Dietary Pi-regulated RNA-1) (Diphor-1) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) |
| Clamp Gene names | | Pdzk1 Clamp Diphor1 Nherf3 |
| Organism | | Rattus norvegicus (Rat) |
| Clamp Entry name | | NHRF3_RAT |
| Clamp Codon optimized cDNA(gene) Clone |
| Clamp Cat # | | RPY1281 |
| Tag | | Clamp contains A 6x histidine tag |
| Clamp Formulation | | Liquid |
| Clamp Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Clamp Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Clamp Protein |
| Clamp Cat # | | PY1281 |
| Clamp Source | | recombinant |
| Clamp Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Clamp Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Clamp Activity | | N/A |
| Tag | | Clamp Contains A 6x histidine tag |
| Clamp Formulation | | Liquid |
| Clamp Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Clamp Products | | For pricing and availability Click Here >>> |
| Clamp family | | NHER family |
| Clamp Subcellular locations | | Cytoplasm. Membrane; Peripheral membrane protein. |
| Clamp FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons. |
| Clamp Sequence | | DDBJ | EMBL | GenBank |
| Clamp 3D structure | | ModBase |
| Clamp interaction | | STRING |
| Clamp Proteomic | | PRIDE |
| Clamp Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Clamp Organism specific | | CTD | MGI |
| Clamp Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Clamp Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Clamp Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
