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Mouse Bardet-Biedl syndrome 4 protein homolog (aa 1-520 )

Bbs4 Swiss Prot#

Q8C1Z7

Bbs4 Protein names

Bardet-Biedl syndrome 4 protein homolog

Bbs4 Gene names

Bbs4

Organism

Mus musculus (Mouse)

Bbs4 Entry name

BBS4_MOUSE

Bbs4 Codon optimized cDNA(gene) Clone

Bbs4 Cat #

RPY1268

Tag

Bbs4 contains A 6x histidine tag

Bbs4 Formulation

Liquid

Bbs4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Bbs4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Bbs4 Protein

Bbs4 Cat #

PY1268

Bbs4 Source

recombinant

Bbs4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Bbs4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Bbs4 Activity

N/A

Tag

Bbs4 Contains A 6x histidine tag

Bbs4 Formulation

Liquid

Bbs4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Bbs4 family

BBS4 family

Bbs4 Subcellular locations

Cytoplasm > cytoskeleton > centrosome. Cell projection > cilium membrane. Cytoplasm.

Bbs4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity).

Bbs4 Sequence

DDBJ

EMBL

GenBank

Bbs4 3D structure

ModBase

Bbs4 interaction

STRING

Bbs4 Proteomic

PRIDE

Bbs4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Bbs4 Organism specific

CTD

MGI

Bbs4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Bbs4 Gene expression

Bgee

ArrayExpress

Genevestigator

Bbs4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY