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Human Na(+) H(+) exchange regulatory c actor NHE-RF3 (aa 1-519 )

CAP70 Swiss Prot#

Q5T2W1

CAP70 Protein names

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)

CAP70 Gene names

PDZK1 CAP70 NHERF3 PDZD1

Organism

Homo sapiens (Human)

CAP70 Entry name

NHRF3_HUMAN

CAP70 Codon optimized cDNA(gene) Clone

CAP70 Cat #

RPY1264

Tag

CAP70 contains A 6x histidine tag

CAP70 Formulation

Liquid

CAP70 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CAP70 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CAP70 Protein

CAP70 Cat #

PY1264

CAP70 Source

recombinant

CAP70 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CAP70 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CAP70 Activity

N/A

Tag

CAP70 Contains A 6x histidine tag

CAP70 Formulation

Liquid

CAP70 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CAP70 family

NHER family

CAP70 Subcellular locations

Cytoplasm. Membrane; Peripheral membrane protein.

CAP70 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

CAP70 Sequence

DDBJ

EMBL

GenBank

CAP70 3D structure

ModBase

CAP70 interaction

STRING

CAP70 Proteomic

PRIDE

CAP70 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CAP70 Organism specific

CTD

MGI

CAP70 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CAP70 Gene expression

Bgee

ArrayExpress

Genevestigator

CAP70 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY