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Mouse Shugoshin-like 1 (aa 1-517 )

Sgo1 Swiss Prot#

Q9CXH7

Sgo1 Protein names

Shugoshin-like 1

Sgo1 Gene names

Sgol1 Sgo1

Organism

Mus musculus (Mouse)

Sgo1 Entry name

SGOL1_MOUSE

Sgo1 Codon optimized cDNA(gene) Clone

Sgo1 Cat #

RPY1261

Tag

Sgo1 contains A 6x histidine tag

Sgo1 Formulation

Liquid

Sgo1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Sgo1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Sgo1 Protein

Sgo1 Cat #

PY1261

Sgo1 Source

recombinant

Sgo1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Sgo1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Sgo1 Activity

N/A

Tag

Sgo1 Contains A 6x histidine tag

Sgo1 Formulation

Liquid

Sgo1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Sgo1 family

Shugoshin family

Sgo1 Subcellular locations

Nucleus. Chromosome > centromere. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle pole. Cytoplasm > cytoskeleton > centrosome.

Sgo1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity.

Sgo1 Sequence

DDBJ

EMBL

GenBank

Sgo1 3D structure

ModBase

Sgo1 interaction

STRING

Sgo1 Proteomic

PRIDE

Sgo1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Sgo1 Organism specific

CTD

MGI

Sgo1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Sgo1 Gene expression

Bgee

ArrayExpress

Genevestigator

Sgo1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY