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Mouse Tetratricopeptide repeat protein 8 (aa 33-515 )

Bbs8 Swiss Prot#

Q8VD72

Bbs8 Protein names

Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein homolog)

Bbs8 Gene names

Ttc8 Bbs8

Organism

Mus musculus (Mouse)

Bbs8 Entry name

TTC8_MOUSE

Bbs8 Codon optimized cDNA(gene) Clone

Bbs8 Cat #

RPY1257

Tag

Bbs8 contains A 6x histidine tag

Bbs8 Formulation

Liquid

Bbs8 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Bbs8 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Bbs8 Protein

Bbs8 Cat #

PY1257

Bbs8 Source

recombinant

Bbs8 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Bbs8 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Bbs8 Activity

N/A

Tag

Bbs8 Contains A 6x histidine tag

Bbs8 Formulation

Liquid

Bbs8 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Bbs8 family

-

Bbs8 Subcellular locations

Cytoplasm > cytoskeleton > centrosome > centriole. Cell projection > cilium membrane. Cytoplasm.

Bbs8 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity).

Bbs8 Sequence

DDBJ

EMBL

GenBank

Bbs8 3D structure

ModBase

Bbs8 interaction

STRING

Bbs8 Proteomic

PRIDE

Bbs8 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Bbs8 Organism specific

CTD

MGI

Bbs8 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Bbs8 Gene expression

Bgee

ArrayExpress

Genevestigator

Bbs8 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY