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Mouse Pre-mRNA-processing factor 19 (aa 10-504 )

Prp19 Swiss Prot#

Q99KP6

Prp19 Protein names

Pre-mRNA-processing factor 19 (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (Senescence evasion factor)

Prp19 Gene names

Prpf19 Prp19 Snev

Organism

Mus musculus (Mouse)

Prp19 Entry name

PRP19_MOUSE

Prp19 Codon optimized cDNA(gene) Clone

Prp19 Cat #

RPY1242

Tag

Prp19 contains A 6x histidine tag

Prp19 Formulation

Liquid

Prp19 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Prp19 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Prp19 Protein

Prp19 Cat #

PY1242

Prp19 Source

recombinant

Prp19 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Prp19 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Prp19 Activity

N/A

Tag

Prp19 Contains A 6x histidine tag

Prp19 Formulation

Liquid

Prp19 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Prp19 family

WD repeat PRP19 family

Prp19 Subcellular locations

Nucleus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle.

Prp19 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process (By similarity).

Prp19 Sequence

DDBJ

EMBL

GenBank

Prp19 3D structure

ModBase

Prp19 interaction

STRING

Prp19 Proteomic

PRIDE

Prp19 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Prp19 Organism specific

CTD

MGI

Prp19 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Prp19 Gene expression

Bgee

ArrayExpress

Genevestigator

Prp19 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY