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Human Pre-mRNA-processing factor 19 (aa 10-504 )

NMP200 Swiss Prot#

Q9UMS4

NMP200 Protein names

Pre-mRNA-processing factor 19 (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (Senescence evasion factor)

NMP200 Gene names

PRPF19 NMP200 PRP19 SNEV

Organism

Homo sapiens (Human)

NMP200 Entry name

PRP19_HUMAN

NMP200 Codon optimized cDNA(gene) Clone

NMP200 Cat #

RPY1240

Tag

NMP200 contains A 6x histidine tag

NMP200 Formulation

Liquid

NMP200 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NMP200 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NMP200 Protein

NMP200 Cat #

PY1240

NMP200 Source

recombinant

NMP200 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NMP200 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NMP200 Activity

N/A

Tag

NMP200 Contains A 6x histidine tag

NMP200 Formulation

Liquid

NMP200 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NMP200 family

WD repeat PRP19 family

NMP200 Subcellular locations

Nucleus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle.

NMP200 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.

NMP200 Sequence

DDBJ

EMBL

GenBank

NMP200 3D structure

ModBase

NMP200 interaction

STRING

NMP200 Proteomic

PRIDE

NMP200 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NMP200 Organism specific

CTD

MGI

NMP200 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NMP200 Gene expression

Bgee

ArrayExpress

Genevestigator

NMP200 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY