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Rat Podocalyxin (aa 24-485 )

Pclp1 Swiss Prot#

Q9WTQ2

Pclp1 Protein names

Podocalyxin (Podocalyxin-like protein 1) (PC) (PCLP-1)

Pclp1 Gene names

Podxl Pclp1

Organism

Rattus norvegicus (Rat)

Pclp1 Entry name

PODXL_RAT

Pclp1 Codon optimized cDNA(gene) Clone

Pclp1 Cat #

RPY1173

Tag

Pclp1 contains A 6x histidine tag

Pclp1 Formulation

Liquid

Pclp1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pclp1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pclp1 Protein

Pclp1 Cat #

PY1173

Pclp1 Source

recombinant

Pclp1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Pclp1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Pclp1 Activity

N/A

Tag

Pclp1 Contains A 6x histidine tag

Pclp1 Formulation

Liquid

Pclp1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pclp1 family

Podocalyxin family

Pclp1 Subcellular locations

Apical cell membrane. Cell projection > microvillus. Membrane raft. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > ruffle. Membrane; Single-pass type I membrane protein.

Pclp1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Pclp1 Sequence

DDBJ

EMBL

GenBank

Pclp1 3D structure

ModBase

Pclp1 interaction

STRING

Pclp1 Proteomic

PRIDE

Pclp1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pclp1 Organism specific

CTD

MGI

Pclp1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pclp1 Gene expression

Bgee

ArrayExpress

Genevestigator

Pclp1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY