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Mouse Abl interactor 1 (aa 13-481 )

Ssh3bp1 Swiss Prot#

Q8CBW3

Ssh3bp1 Protein names

Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)

Ssh3bp1 Gene names

Abi1 Ssh3bp1

Organism

Mus musculus (Mouse)

Ssh3bp1 Entry name

ABI1_MOUSE

Ssh3bp1 Codon optimized cDNA(gene) Clone

Ssh3bp1 Cat #

RPY1162

Tag

Ssh3bp1 contains A 6x histidine tag

Ssh3bp1 Formulation

Liquid

Ssh3bp1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ssh3bp1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ssh3bp1 Protein

Ssh3bp1 Cat #

PY1162

Ssh3bp1 Source

recombinant

Ssh3bp1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ssh3bp1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ssh3bp1 Activity

N/A

Tag

Ssh3bp1 Contains A 6x histidine tag

Ssh3bp1 Formulation

Liquid

Ssh3bp1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ssh3bp1 family

ABI family

Ssh3bp1 Subcellular locations

Cytoplasm. Nucleus. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton.

Ssh3bp1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Ssh3bp1 Sequence

DDBJ

EMBL

GenBank

Ssh3bp1 3D structure

ModBase

Ssh3bp1 interaction

STRING

Ssh3bp1 Proteomic

PRIDE

Ssh3bp1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ssh3bp1 Organism specific

CTD

MGI

Ssh3bp1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ssh3bp1 Gene expression

Bgee

ArrayExpress

Genevestigator

Ssh3bp1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY