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Rat Abl interactor 1 (aa 13-476 )

Abi1 Swiss Prot#

Q9QZM5

Abi1 Protein names

Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1)

Abi1 Gene names

Abi1

Organism

Rattus norvegicus (Rat)

Abi1 Entry name

ABI1_RAT

Abi1 Codon optimized cDNA(gene) Clone

Abi1 Cat #

RPY1146

Tag

Abi1 contains A 6x histidine tag

Abi1 Formulation

Liquid

Abi1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Abi1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Abi1 Protein

Abi1 Cat #

PY1146

Abi1 Source

recombinant

Abi1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Abi1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Abi1 Activity

N/A

Tag

Abi1 Contains A 6x histidine tag

Abi1 Formulation

Liquid

Abi1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Abi1 family

ABI family

Abi1 Subcellular locations

Cytoplasm. Nucleus. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton.

Abi1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity).

Abi1 Sequence

DDBJ

EMBL

GenBank

Abi1 3D structure

ModBase

Abi1 interaction

STRING

Abi1 Proteomic

PRIDE

Abi1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Abi1 Organism specific

CTD

MGI

Abi1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Abi1 Gene expression

Bgee

ArrayExpress

Genevestigator

Abi1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY