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Mouse Intraflagellar transport protein 57 homolog (aa 1-429 )

Hippi Swiss Prot#

Q8BXG3

Hippi Protein names

Intraflagellar transport protein 57 homolog (HIP1-interacting protein)

Hippi Gene names

Ift57 Hippi

Organism

Mus musculus (Mouse)

Hippi Entry name

IFT57_MOUSE

Hippi Codon optimized cDNA(gene) Clone

Hippi Cat #

RPY0962

Tag

Hippi contains A 6x histidine tag

Hippi Formulation

Liquid

Hippi Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Hippi Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Hippi Protein

Hippi Cat #

PY0962

Hippi Source

recombinant

Hippi Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Hippi Purity

>90%, as determined by SDS-PAGE under reducing conditions

Hippi Activity

N/A

Tag

Hippi Contains A 6x histidine tag

Hippi Formulation

Liquid

Hippi Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Hippi family

IFT57 family

Hippi Subcellular locations

Cytoplasm > cytoskeleton > cilium basal body. Golgi apparatus.

Hippi FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Hippi Sequence

DDBJ

EMBL

GenBank

Hippi 3D structure

ModBase

Hippi interaction

STRING

Hippi Proteomic

PRIDE

Hippi Genome annotation

Ensembl

GeneID

KEGG

UCSC

Hippi Organism specific

CTD

MGI

Hippi Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Hippi Gene expression

Bgee

ArrayExpress

Genevestigator

Hippi Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY