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Mouse Proline-serine-threonine phosphatase-interacting 1 (aa 1-415 )

Pstpip1 Swiss Prot#

P97814

Pstpip1 Protein names

Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1)

Pstpip1 Gene names

Pstpip1

Organism

Mus musculus (Mouse)

Pstpip1 Entry name

PPIP1_MOUSE

Pstpip1 Codon optimized cDNA(gene) Clone

Pstpip1 Cat #

RPY0902

Tag

Pstpip1 contains A 6x histidine tag

Pstpip1 Formulation

Liquid

Pstpip1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pstpip1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pstpip1 Protein

Pstpip1 Cat #

PY0902

Pstpip1 Source

recombinant

Pstpip1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Pstpip1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Pstpip1 Activity

N/A

Tag

Pstpip1 Contains A 6x histidine tag

Pstpip1 Formulation

Liquid

Pstpip1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pstpip1 family

-

Pstpip1 Subcellular locations

Cytoplasm. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cytoplasm > perinuclear region. Cleavage furrow.

Pstpip1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2.

Pstpip1 Sequence

DDBJ

EMBL

GenBank

Pstpip1 3D structure

ModBase

Pstpip1 interaction

STRING

Pstpip1 Proteomic

PRIDE

Pstpip1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pstpip1 Organism specific

CTD

MGI

Pstpip1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pstpip1 Gene expression

Bgee

ArrayExpress

Genevestigator

Pstpip1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY