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Human Platelet-activating factor acetylhydrolase IB alpha (aa 1-410 )

LIS1 Swiss Prot#

P43034

LIS1 Protein names

Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)

LIS1 Gene names

PAFAH1B1 LIS1 MDCR MDS PAFAHA

Organism

Homo sapiens (Human)

LIS1 Entry name

LIS1_HUMAN

LIS1 Codon optimized cDNA(gene) Clone

LIS1 Cat #

RPY0881

Tag

LIS1 contains A 6x histidine tag

LIS1 Formulation

Liquid

LIS1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

LIS1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant LIS1 Protein

LIS1 Cat #

PY0881

LIS1 Source

recombinant

LIS1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

LIS1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

LIS1 Activity

N/A

Tag

LIS1 Contains A 6x histidine tag

LIS1 Formulation

Liquid

LIS1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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LIS1 family

WD repeat LIS1/nudF family

LIS1 Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Nucleus membrane.

LIS1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.

LIS1 Sequence

DDBJ

EMBL

GenBank

LIS1 3D structure

ModBase

LIS1 interaction

STRING

LIS1 Proteomic

PRIDE

LIS1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

LIS1 Organism specific

CTD

MGI

LIS1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

LIS1 Gene expression

Bgee

ArrayExpress

Genevestigator

LIS1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY