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Rat Proline-rich protein 5 (aa 1-387 )

Protor1 Swiss Prot#

Q5FVG6

Protor1 Protein names

Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1)

Protor1 Gene names

Prr5 Protor1

Organism

Rattus norvegicus (Rat)

Protor1 Entry name

PRR5_RAT

Protor1 Codon optimized cDNA(gene) Clone

Protor1 Cat #

RPY0825

Tag

Protor1 contains A 6x histidine tag

Protor1 Formulation

Liquid

Protor1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Protor1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Protor1 Protein

Protor1 Cat #

PY0825

Protor1 Source

recombinant

Protor1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Protor1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Protor1 Activity

N/A

Tag

Protor1 Contains A 6x histidine tag

Protor1 Formulation

Liquid

Protor1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Protor1 family

PROTOR family

Protor1 Subcellular locations

-

Protor1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).

Protor1 Sequence

DDBJ

EMBL

GenBank

Protor1 3D structure

ModBase

Protor1 interaction

STRING

Protor1 Proteomic

PRIDE

Protor1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Protor1 Organism specific

CTD

MGI

Protor1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Protor1 Gene expression

Bgee

ArrayExpress

Genevestigator

Protor1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY