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Human Septin-2 (aa 1-361 )

DIFF6 Swiss Prot#

Q15019

DIFF6 Protein names

Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)

DIFF6 Gene names

SEPT2 DIFF6 KIAA0158 NEDD5

Organism

Homo sapiens (Human)

DIFF6 Entry name

SEPT2_HUMAN

DIFF6 Codon optimized cDNA(gene) Clone

DIFF6 Cat #

RPY0727

Tag

DIFF6 contains A 6x histidine tag

DIFF6 Formulation

Liquid

DIFF6 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DIFF6 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DIFF6 Protein

DIFF6 Cat #

PY0727

DIFF6 Source

recombinant

DIFF6 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DIFF6 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DIFF6 Activity

N/A

Tag

DIFF6 Contains A 6x histidine tag

DIFF6 Formulation

Liquid

DIFF6 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DIFF6 family

Septin family

DIFF6 Subcellular locations

Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. Cleavage furrow. Midbody.

DIFF6 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

DIFF6 Sequence

DDBJ

EMBL

GenBank

DIFF6 3D structure

ModBase

DIFF6 interaction

STRING

DIFF6 Proteomic

PRIDE

DIFF6 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DIFF6 Organism specific

CTD

MGI

DIFF6 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DIFF6 Gene expression

Bgee

ArrayExpress

Genevestigator

DIFF6 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY