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Rat Dysbindin (aa 1-352 )

Dtnbp1 Swiss Prot#

Q5M834

Dtnbp1 Protein names

Dysbindin (Dysbindin-1) (Dystrobrevin-binding protein 1)

Dtnbp1 Gene names

Dtnbp1

Organism

Rattus norvegicus (Rat)

Dtnbp1 Entry name

DTBP1_RAT

Dtnbp1 Codon optimized cDNA(gene) Clone

Dtnbp1 Cat #

RPY0702

Tag

Dtnbp1 contains A 6x histidine tag

Dtnbp1 Formulation

Liquid

Dtnbp1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Dtnbp1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Dtnbp1 Protein

Dtnbp1 Cat #

PY0702

Dtnbp1 Source

recombinant

Dtnbp1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Dtnbp1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Dtnbp1 Activity

N/A

Tag

Dtnbp1 Contains A 6x histidine tag

Dtnbp1 Formulation

Liquid

Dtnbp1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Dtnbp1 family

Dysbindin family

Dtnbp1 Subcellular locations

Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Endoplasmic reticulum.

Dtnbp1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.

Dtnbp1 Sequence

DDBJ

EMBL

GenBank

Dtnbp1 3D structure

ModBase

Dtnbp1 interaction

STRING

Dtnbp1 Proteomic

PRIDE

Dtnbp1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Dtnbp1 Organism specific

CTD

MGI

Dtnbp1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Dtnbp1 Gene expression

Bgee

ArrayExpress

Genevestigator

Dtnbp1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY