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Mouse Dysbindin (aa 1-352 )

Sdy Swiss Prot#

Q91WZ8

Sdy Protein names

Dysbindin (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein homolog) (HPS7 protein homolog)

Sdy Gene names

Dtnbp1 Sdy

Organism

Mus musculus (Mouse)

Sdy Entry name

DTBP1_MOUSE

Sdy Codon optimized cDNA(gene) Clone

Sdy Cat #

RPY0699

Tag

Sdy contains A 6x histidine tag

Sdy Formulation

Liquid

Sdy Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Sdy Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Sdy Protein

Sdy Cat #

PY0699

Sdy Source

recombinant

Sdy Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Sdy Purity

>90%, as determined by SDS-PAGE under reducing conditions

Sdy Activity

N/A

Tag

Sdy Contains A 6x histidine tag

Sdy Formulation

Liquid

Sdy Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Sdy family

Dysbindin family

Sdy Subcellular locations

Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Endoplasmic reticulum. Nucleus.

Sdy FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.

Sdy Sequence

DDBJ

EMBL

GenBank

Sdy 3D structure

ModBase

Sdy interaction

STRING

Sdy Proteomic

PRIDE

Sdy Genome annotation

Ensembl

GeneID

KEGG

UCSC

Sdy Organism specific

CTD

MGI

Sdy Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Sdy Gene expression

Bgee

ArrayExpress

Genevestigator

Sdy Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY