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Mouse Nuclear distribution protein nudE-like 1 (aa 1-345 )

Nudel Swiss Prot#

Q9ERR1

Nudel Protein names

Nuclear distribution protein nudE-like 1 (Protein mNudE-like) (Protein Nudel) (mNudE-L)

Nudel Gene names

Ndel1 Nudel

Organism

Mus musculus (Mouse)

Nudel Entry name

NDEL1_MOUSE

Nudel Codon optimized cDNA(gene) Clone

Nudel Cat #

RPY0664

Tag

Nudel contains A 6x histidine tag

Nudel Formulation

Liquid

Nudel Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nudel Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nudel Protein

Nudel Cat #

PY0664

Nudel Source

recombinant

Nudel Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nudel Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nudel Activity

N/A

Tag

Nudel Contains A 6x histidine tag

Nudel Formulation

Liquid

Nudel Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Nudel family

NudE family

Nudel Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle.

Nudel FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Nudel Sequence

DDBJ

EMBL

GenBank

Nudel 3D structure

ModBase

Nudel interaction

STRING

Nudel Proteomic

PRIDE

Nudel Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nudel Organism specific

CTD

MGI

Nudel Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nudel Gene expression

Bgee

ArrayExpress

Genevestigator

Nudel Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY