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Human Nuclear distribution protein nudE-like 1 (aa 1-345 )
EOPA Swiss Prot#
Q9GZM8
EOPA Protein names
Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
EOPA Gene names
NDEL1 EOPA MITAP1 NUDEL
Organism
Homo sapiens (Human)
EOPA Entry name
NDEL1_HUMAN
EOPA Codon optimized cDNA(gene) Clone
EOPA Cat #
RPY0662
Tag
EOPA contains A 6x histidine tag
EOPA Formulation
Liquid
EOPA Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
EOPA Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant EOPA Protein
EOPA Cat #
PY0662
EOPA Source
recombinant
EOPA Applications
Western Blot, SDS-Page or may be used for other applications determined by user
EOPA Purity
>90%, as determined by SDS-PAGE under reducing conditions
EOPA Activity
N/A
Tag
EOPA Contains A 6x histidine tag
EOPA Formulation
Liquid
EOPA Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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EOPA family
NudE family
EOPA Subcellular locations
Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle.
EOPA FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
EOPA Sequence
DDBJ EMBL GenBank
EOPA 3D structure
ModBase
EOPA interaction
STRING
EOPA Proteomic
PRIDE
EOPA Genome annotation
Ensembl GeneID KEGG UCSC
EOPA Organism specific
CTD MGI
EOPA Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
EOPA Gene expression
Bgee ArrayExpress Genevestigator
EOPA Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY