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Human Ras association domain-containing protein 1 (aa 20-344 )

RDA32 Swiss Prot#

Q9NS23

RDA32 Protein names

Ras association domain-containing protein 1

RDA32 Gene names

RASSF1 RDA32

Organism

Homo sapiens (Human)

RDA32 Entry name

RASF1_HUMAN

RDA32 Codon optimized cDNA(gene) Clone

RDA32 Cat #

RPY0658

Tag

RDA32 contains A 6x histidine tag

RDA32 Formulation

Liquid

RDA32 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RDA32 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RDA32 Protein

RDA32 Cat #

PY0658

RDA32 Source

recombinant

RDA32 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RDA32 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RDA32 Activity

N/A

Tag

RDA32 Contains A 6x histidine tag

RDA32 Formulation

Liquid

RDA32 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RDA32 family

-

RDA32 Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Nucleus. Nucleus.

RDA32 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK4 during Fas-induced apoptosis. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

RDA32 Sequence

DDBJ

EMBL

GenBank

RDA32 3D structure

ModBase

RDA32 interaction

STRING

RDA32 Proteomic

PRIDE

RDA32 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RDA32 Organism specific

CTD

MGI

RDA32 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RDA32 Gene expression

Bgee

ArrayExpress

Genevestigator

RDA32 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY