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Mouse Ras association domain-containing protein 1 (aa 10-340 )

Rassf1 Swiss Prot#

Q99MK9

Rassf1 Protein names

Ras association domain-containing protein 1 (Protein 123F2)

Rassf1 Gene names

Rassf1

Organism

Mus musculus (Mouse)

Rassf1 Entry name

RASF1_MOUSE

Rassf1 Codon optimized cDNA(gene) Clone

Rassf1 Cat #

RPY0650

Tag

Rassf1 contains A 6x histidine tag

Rassf1 Formulation

Liquid

Rassf1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Rassf1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Rassf1 Protein

Rassf1 Cat #

PY0650

Rassf1 Source

recombinant

Rassf1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Rassf1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Rassf1 Activity

N/A

Tag

Rassf1 Contains A 6x histidine tag

Rassf1 Formulation

Liquid

Rassf1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Rassf1 family

-

Rassf1 Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Nucleus.

Rassf1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK4 during Fas-induced apoptosis. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity).

Rassf1 Sequence

DDBJ

EMBL

GenBank

Rassf1 3D structure

ModBase

Rassf1 interaction

STRING

Rassf1 Proteomic

PRIDE

Rassf1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Rassf1 Organism specific

CTD

MGI

Rassf1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Rassf1 Gene expression

Bgee

ArrayExpress

Genevestigator

Rassf1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY