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Rat PRKC apoptosis WT1 regulator protein (aa 1-332 )

Par4 Swiss Prot#

Q62627

Par4 Protein names

PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Transcriptional repressor Par-4-like protein PAWR)

Par4 Gene names

Pawr Par4

Organism

Rattus norvegicus (Rat)

Par4 Entry name

PAWR_RAT

Par4 Codon optimized cDNA(gene) Clone

Par4 Cat #

RPY0629

Tag

Par4 contains A 6x histidine tag

Par4 Formulation

Liquid

Par4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Par4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Par4 Protein

Par4 Cat #

PY0629

Par4 Source

recombinant

Par4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Par4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Par4 Activity

N/A

Tag

Par4 Contains A 6x histidine tag

Par4 Formulation

Liquid

Par4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Par4 family

-

Par4 Subcellular locations

Cytoplasm. Nucleus.

Par4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).

Par4 Sequence

DDBJ

EMBL

GenBank

Par4 3D structure

ModBase

Par4 interaction

STRING

Par4 Proteomic

PRIDE

Par4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Par4 Organism specific

CTD

MGI

Par4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Par4 Gene expression

Bgee

ArrayExpress

Genevestigator

Par4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY