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Mouse BTB POZ domain-containing adapter CUL3 (aa 1-316 )

Edp1 Swiss Prot#

O70479

Edp1 Protein names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BTB/POZ domain-containing protein TNFAIP1) (Tumor necrosis factor, alpha-induced protein 1, endothelial)

Edp1 Gene names

Tnfaip1 Edp1

Organism

Mus musculus (Mouse)

Edp1 Entry name

BACD2_MOUSE

Edp1 Codon optimized cDNA(gene) Clone

Edp1 Cat #

RPY0582

Tag

Edp1 contains A 6x histidine tag

Edp1 Formulation

Liquid

Edp1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Edp1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Edp1 Protein

Edp1 Cat #

PY0582

Edp1 Source

recombinant

Edp1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Edp1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Edp1 Activity

N/A

Tag

Edp1 Contains A 6x histidine tag

Edp1 Formulation

Liquid

Edp1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Edp1 family

BACURD family

Edp1 Subcellular locations

Cytoplasm. Nucleus. Endosome.

Edp1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).

Edp1 Sequence

DDBJ

EMBL

GenBank

Edp1 3D structure

ModBase

Edp1 interaction

STRING

Edp1 Proteomic

PRIDE

Edp1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Edp1 Organism specific

CTD

MGI

Edp1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Edp1 Gene expression

Bgee

ArrayExpress

Genevestigator

Edp1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY