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Human BTB POZ domain-containing adapter CUL3 (aa 1-316 )

BACURD2 Swiss Prot#

Q13829

BACURD2 Protein names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)

BACURD2 Gene names

TNFAIP1 BACURD2 EDP1

Organism

Homo sapiens (Human)

BACURD2 Entry name

BACD2_HUMAN

BACURD2 Codon optimized cDNA(gene) Clone

BACURD2 Cat #

RPY0581

Tag

BACURD2 contains A 6x histidine tag

BACURD2 Formulation

Liquid

BACURD2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BACURD2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BACURD2 Protein

BACURD2 Cat #

PY0581

BACURD2 Source

recombinant

BACURD2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BACURD2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

BACURD2 Activity

N/A

Tag

BACURD2 Contains A 6x histidine tag

BACURD2 Formulation

Liquid

BACURD2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BACURD2 family

BACURD family

BACURD2 Subcellular locations

Cytoplasm. Nucleus. Endosome.

BACURD2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

BACURD2 Sequence

DDBJ

EMBL

GenBank

BACURD2 3D structure

ModBase

BACURD2 interaction

STRING

BACURD2 Proteomic

PRIDE

BACURD2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

BACURD2 Organism specific

CTD

MGI

BACURD2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BACURD2 Gene expression

Bgee

ArrayExpress

Genevestigator

BACURD2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY