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Human RBPJ-interacting tubulin-associated protein (aa 1-269 )

C12orf52 Swiss Prot#

Q96K30

C12orf52 Protein names

RBPJ-interacting and tubulin-associated protein

C12orf52 Gene names

RITA C12orf52 PSEC0043

Organism

Homo sapiens (Human)

C12orf52 Entry name

RITA_HUMAN

C12orf52 Codon optimized cDNA(gene) Clone

C12orf52 Cat #

RPY0429

Tag

C12orf52 contains A 6x histidine tag

C12orf52 Formulation

Liquid

C12orf52 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

C12orf52 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant C12orf52 Protein

C12orf52 Cat #

PY0429

C12orf52 Source

recombinant

C12orf52 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

C12orf52 Purity

>90%, as determined by SDS-PAGE under reducing conditions

C12orf52 Activity

N/A

Tag

C12orf52 Contains A 6x histidine tag

C12orf52 Formulation

Liquid

C12orf52 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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C12orf52 family

RITA family

C12orf52 Subcellular locations

Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.

C12orf52 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

C12orf52 Sequence

DDBJ

EMBL

GenBank

C12orf52 3D structure

ModBase

C12orf52 interaction

STRING

C12orf52 Proteomic

PRIDE

C12orf52 Genome annotation

Ensembl

GeneID

KEGG

UCSC

C12orf52 Organism specific

CTD

MGI

C12orf52 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

C12orf52 Gene expression

Bgee

ArrayExpress

Genevestigator

C12orf52 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY