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Mouse Spindle kinetochore-associated protein 1 (aa 1-254 )

Ska1 Swiss Prot#

Q9CPV1

Ska1 Protein names

Spindle and kinetochore-associated protein 1

Ska1 Gene names

Ska1

Organism

Mus musculus (Mouse)

Ska1 Entry name

SKA1_MOUSE

Ska1 Codon optimized cDNA(gene) Clone

Ska1 Cat #

RPY0405

Tag

Ska1 contains A 6x histidine tag

Ska1 Formulation

Liquid

Ska1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ska1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ska1 Protein

Ska1 Cat #

PY0405

Ska1 Source

recombinant

Ska1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ska1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ska1 Activity

N/A

Tag

Ska1 Contains A 6x histidine tag

Ska1 Formulation

Liquid

Ska1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ska1 family

SKA1 family

Ska1 Subcellular locations

Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore.

Ska1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules (By similarity).

Ska1 Sequence

DDBJ

EMBL

GenBank

Ska1 3D structure

ModBase

Ska1 interaction

STRING

Ska1 Proteomic

PRIDE

Ska1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ska1 Organism specific

CTD

MGI

Ska1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ska1 Gene expression

Bgee

ArrayExpress

Genevestigator

Ska1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY