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Human Methylosome subunit pICln (aa 1-237 )

CLCI Swiss Prot#

P54105

CLCI Protein names

Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)

CLCI Gene names

CLNS1A CLCI ICLN

Organism

Homo sapiens (Human)

CLCI Entry name

ICLN_HUMAN

CLCI Codon optimized cDNA(gene) Clone

CLCI Cat #

RPY0363

Tag

CLCI contains A 6x histidine tag

CLCI Formulation

Liquid

CLCI Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CLCI Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CLCI Protein

CLCI Cat #

PY0363

CLCI Source

recombinant

CLCI Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CLCI Purity

>90%, as determined by SDS-PAGE under reducing conditions

CLCI Activity

N/A

Tag

CLCI Contains A 6x histidine tag

CLCI Formulation

Liquid

CLCI Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CLCI family

PICln family

CLCI Subcellular locations

Cytoplasm. Nucleus. Cytoplasm > cytoskeleton.

CLCI FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

CLCI Sequence

DDBJ

EMBL

GenBank

CLCI 3D structure

ModBase

CLCI interaction

STRING

CLCI Proteomic

PRIDE

CLCI Genome annotation

Ensembl

GeneID

KEGG

UCSC

CLCI Organism specific

CTD

MGI

CLCI Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CLCI Gene expression

Bgee

ArrayExpress

Genevestigator

CLCI Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY