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Human Protein lin-7 homolog A (aa 1-233 )

MALS1 Swiss Prot#

O14910

MALS1 Protein names

Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)

MALS1 Gene names

LIN7A MALS1 VELI1

Organism

Homo sapiens (Human)

MALS1 Entry name

LIN7A_HUMAN

MALS1 Codon optimized cDNA(gene) Clone

MALS1 Cat #

RPY0353

Tag

MALS1 contains A 6x histidine tag

MALS1 Formulation

Liquid

MALS1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MALS1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MALS1 Protein

MALS1 Cat #

PY0353

MALS1 Source

recombinant

MALS1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MALS1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MALS1 Activity

N/A

Tag

MALS1 Contains A 6x histidine tag

MALS1 Formulation

Liquid

MALS1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MALS1 family

Lin-7 family

MALS1 Subcellular locations

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density; Peripheral membrane protein. Cell junction > tight junction. Cell junction > synapse > synaptosome.

MALS1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

MALS1 Sequence

DDBJ

EMBL

GenBank

MALS1 3D structure

ModBase

MALS1 interaction

STRING

MALS1 Proteomic

PRIDE

MALS1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MALS1 Organism specific

CTD

MGI

MALS1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MALS1 Gene expression

Bgee

ArrayExpress

Genevestigator

MALS1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY