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Human 26S proteasome non-ATPase regulatory subunit 10 (aa 18-226 )

PSMD10 Swiss Prot#

O75832

PSMD10 Protein names

26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))

PSMD10 Gene names

PSMD10

Organism

Homo sapiens (Human)

PSMD10 Entry name

PSD10_HUMAN

PSMD10 Codon optimized cDNA(gene) Clone

PSMD10 Cat #

RPY0341

Tag

PSMD10 contains A 6x histidine tag

PSMD10 Formulation

Liquid

PSMD10 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PSMD10 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PSMD10 Protein

PSMD10 Cat #

PY0341

PSMD10 Source

recombinant

PSMD10 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PSMD10 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PSMD10 Activity

N/A

Tag

PSMD10 Contains A 6x histidine tag

PSMD10 Formulation

Liquid

PSMD10 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PSMD10 family

-

PSMD10 Subcellular locations

Cytoplasm. Nucleus.

PSMD10 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteosomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

PSMD10 Sequence

DDBJ

EMBL

GenBank

PSMD10 3D structure

ModBase

PSMD10 interaction

STRING

PSMD10 Proteomic

PRIDE

PSMD10 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PSMD10 Organism specific

CTD

MGI

PSMD10 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PSMD10 Gene expression

Bgee

ArrayExpress

Genevestigator

PSMD10 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY