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Human Protein lin-7 homolog B (aa 1-207 )

MALS2 Swiss Prot#

Q9HAP6

MALS2 Protein names

Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)

MALS2 Gene names

LIN7B MALS2 VELI2 UNQ3116/PRO10200

Organism

Homo sapiens (Human)

MALS2 Entry name

LIN7B_HUMAN

MALS2 Codon optimized cDNA(gene) Clone

MALS2 Cat #

RPY0294

Tag

MALS2 contains A 6x histidine tag

MALS2 Formulation

Liquid

MALS2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MALS2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MALS2 Protein

MALS2 Cat #

PY0294

MALS2 Source

recombinant

MALS2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MALS2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MALS2 Activity

N/A

Tag

MALS2 Contains A 6x histidine tag

MALS2 Formulation

Liquid

MALS2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MALS2 family

Lin-7 family

MALS2 Subcellular locations

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density; Peripheral membrane protein. Cell junction > tight junction. Cell junction > synapse > synaptosome.

MALS2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

MALS2 Sequence

DDBJ

EMBL

GenBank

MALS2 3D structure

ModBase

MALS2 interaction

STRING

MALS2 Proteomic

PRIDE

MALS2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MALS2 Organism specific

CTD

MGI

MALS2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MALS2 Gene expression

Bgee

ArrayExpress

Genevestigator

MALS2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY