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Mouse Spindle kinetochore-associated protein 2 (aa 1-120 )

Ska2 Swiss Prot#

Q9CR46

Ska2 Protein names

Spindle and kinetochore-associated protein 2 (Protein FAM33A)

Ska2 Gene names

Ska2 Fam33a

Organism

Mus musculus (Mouse)

Ska2 Entry name

SKA2_MOUSE

Ska2 Codon optimized cDNA(gene) Clone

Ska2 Cat #

RPY0059

Tag

Ska2 contains A 6x histidine tag

Ska2 Formulation

Liquid

Ska2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Ska2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Ska2 Protein

Ska2 Cat #

PY0059

Ska2 Source

recombinant

Ska2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Ska2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Ska2 Activity

N/A

Tag

Ska2 Contains A 6x histidine tag

Ska2 Formulation

Liquid

Ska2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Ska2 family

SKA2 family

Ska2 Subcellular locations

Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore.

Ska2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization (By similarity).

Ska2 Sequence

DDBJ

EMBL

GenBank

Ska2 3D structure

ModBase

Ska2 interaction

STRING

Ska2 Proteomic

PRIDE

Ska2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Ska2 Organism specific

CTD

MGI

Ska2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Ska2 Gene expression

Bgee

ArrayExpress

Genevestigator

Ska2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY