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Human Protein S100-A8 (aa 1-93 )

S100A8 Swiss Prot#

P05109

S100A8 Protein names

Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)

S100A8 Gene names

S100A8 CAGA CFAG MRP8

Organism

Homo sapiens (Human)

S100A8 Entry name

S10A8_HUMAN

S100A8 Codon optimized cDNA(gene) Clone

S100A8 Cat #

RPY0020

Tag

S100A8 contains A 6x histidine tag

S100A8 Formulation

Liquid

S100A8 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

S100A8 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant S100A8 Protein

S100A8 Cat #

PY0020

S100A8 Source

recombinant

S100A8 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

S100A8 Purity

>90%, as determined by SDS-PAGE under reducing conditions

S100A8 Activity

N/A

Tag

S100A8 Contains A 6x histidine tag

S100A8 Formulation

Liquid

S100A8 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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S100A8 family

S-100 family

S100A8 Subcellular locations

Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane; Peripheral membrane protein.

S100A8 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.

S100A8 Sequence

DDBJ

EMBL

GenBank

S100A8 3D structure

ModBase

S100A8 interaction

STRING

S100A8 Proteomic

PRIDE

S100A8 Genome annotation

Ensembl

GeneID

KEGG

UCSC

S100A8 Organism specific

CTD

MGI

S100A8 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

S100A8 Gene expression

Bgee

ArrayExpress

Genevestigator

S100A8 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY