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Rat Tyrosine phosphatase non-1-receptor type 1 (aa 32-509)

Bit Swiss Prot#

P97710

Bit Protein names

Tyrosine-protein phosphatase non-1-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Inhibitory 1-receptor SHPS-1) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion 1-receptor) (Macrophage membrane protein MFP150) (CD172 antigen-like family member A) (CD antigen CD172a)

Bit Gene names

Sirpa (Bit) (Mfr) (Ptpns1) (Shps1) (Sirp)

Organism

Rat

Bit Entry name

SHPS1_RAT

Bit Codon optimized cDNA(gene) Clone

Bit Cat #

RPA0940

Tag

Bit contains A 6x histidine tag

Bit Formulation

Liquid

Bit Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Bit Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Bit Protein

Bit Cat #

PA0940

Bit Source

recombinant

Bit Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Bit Purity

>90%, as determined by SDS-PAGE under reducing conditions

Bit Activity

N/A

Tag

Bit Contains A 6x histidine tag

Bit Formulation

Liquid

Bit Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Bit family

-

Bit Subcellular locations

Membrane; Single-pass type I membrane protein.

Bit FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages (By similarity).

Bit Sequence

DDBJ

EMBL

GenBank

Bit 3D structure

ModBase

Bit interaction

STRING

Bit Proteomic

PRIDE

Bit Genome annotation

Ensembl

GeneID

KEGG

UCSC

Bit Organism specific

CTD

MGI

Bit Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Bit Gene expression

Bgee

ArrayExpress

Genevestigator

Bit Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY