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Rat Tumor necrosis factor 1-receptor superfamily 11B (aa 22-401)

Opg Swiss Prot#

O08727

Opg Protein names

Tumor necrosis factor 1-receptor superfamily member 11B (Osteoprotegerin)

Opg Gene names

Tnfrsf11b (Opg)

Organism

Rat

Opg Entry name

TR11B_RAT

Opg Codon optimized cDNA(gene) Clone

Opg Cat #

RPA0938

Tag

Opg contains A 6x histidine tag

Opg Formulation

Liquid

Opg Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Opg Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Opg Protein

Opg Cat #

PA0938

Opg Source

recombinant

Opg Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Opg Purity

>90%, as determined by SDS-PAGE under reducing conditions

Opg Activity

N/A

Tag

Opg Contains A 6x histidine tag

Opg Formulation

Liquid

Opg Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Opg family

-

Opg Subcellular locations

Secreted.

Opg FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).

Opg Sequence

DDBJ

EMBL

GenBank

Opg 3D structure

ModBase

Opg interaction

STRING

Opg Proteomic

PRIDE

Opg Genome annotation

Ensembl

GeneID

KEGG

UCSC

Opg Organism specific

CTD

MGI

Opg Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Opg Gene expression

Bgee

ArrayExpress

Genevestigator

Opg Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY