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Rat Tnf 1-receptor-associated factor 6 (aa 1-530)

Traf6_predicted Swiss Prot#

B5DF45

Traf6_predicted Protein names

Tnf 1-receptor-associated factor 6 (Predicted)

Traf6_predicted Gene names

Traf6 (Traf6_predicted) (rCG_26813)

Organism

Rat

Traf6_predicted Entry name

TRAF6_RAT

Traf6_predicted Codon optimized cDNA(gene) Clone

Traf6_predicted Cat #

RPA0930

Tag

Traf6_predicted contains A 6x histidine tag

Traf6_predicted Formulation

Liquid

Traf6_predicted Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Traf6_predicted Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Traf6_predicted Protein

Traf6_predicted Cat #

PA0930

Traf6_predicted Source

recombinant

Traf6_predicted Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Traf6_predicted Purity

>90%, as determined by SDS-PAGE under reducing conditions

Traf6_predicted Activity

N/A

Tag

Traf6_predicted Contains A 6x histidine tag

Traf6_predicted Formulation

Liquid

Traf6_predicted Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Traf6_predicted family

TNF receptor-associated factor family, A subfamily

Traf6_predicted Subcellular locations

Cytoplasm. Cytoplasm > cell cortex. Nucleus.

Traf6_predicted FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity).

Traf6_predicted Sequence

DDBJ

EMBL

GenBank

Traf6_predicted 3D structure

ModBase

Traf6_predicted interaction

STRING

Traf6_predicted Proteomic

PRIDE

Traf6_predicted Genome annotation

Ensembl

GeneID

KEGG

UCSC

Traf6_predicted Organism specific

CTD

MGI

Traf6_predicted Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Traf6_predicted Gene expression

Bgee

ArrayExpress

Genevestigator

Traf6_predicted Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY