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Rat Suppressor of cytokine signaling 3 (aa 1-225)

Cish3 Swiss Prot#

O88583

Cish3 Protein names

Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3)

Cish3 Gene names

Socs3 (Cish3)

Organism

Rat

Cish3 Entry name

SOCS3_RAT

Cish3 Codon optimized cDNA(gene) Clone

Cish3 Cat #

RPA0926

Tag

Cish3 contains A 6x histidine tag

Cish3 Formulation

Liquid

Cish3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cish3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cish3 Protein

Cish3 Cat #

PA0926

Cish3 Source

recombinant

Cish3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cish3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cish3 Activity

N/A

Tag

Cish3 Contains A 6x histidine tag

Cish3 Formulation

Liquid

Cish3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cish3 family

-

Cish3 Subcellular locations

-

Cish3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Cish3 Sequence

DDBJ

EMBL

GenBank

Cish3 3D structure

ModBase

Cish3 interaction

STRING

Cish3 Proteomic

PRIDE

Cish3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cish3 Organism specific

CTD

MGI

Cish3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cish3 Gene expression

Bgee

ArrayExpress

Genevestigator

Cish3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY