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Rat Suppressor of cytokine signaling 2 (aa 1-198)

Cish2 Swiss Prot#

O88582

Cish2 Protein names

Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)

Cish2 Gene names

Socs2 (Cish2)

Organism

Rat

Cish2 Entry name

SOCS2_RAT

Cish2 Codon optimized cDNA(gene) Clone

Cish2 Cat #

RPA0925

Tag

Cish2 contains A 6x histidine tag

Cish2 Formulation

Liquid

Cish2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cish2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cish2 Protein

Cish2 Cat #

PA0925

Cish2 Source

recombinant

Cish2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cish2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cish2 Activity

N/A

Tag

Cish2 Contains A 6x histidine tag

Cish2 Formulation

Liquid

Cish2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cish2 family

-

Cish2 Subcellular locations

-

Cish2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Cish2 Sequence

DDBJ

EMBL

GenBank

Cish2 3D structure

ModBase

Cish2 interaction

STRING

Cish2 Proteomic

PRIDE

Cish2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cish2 Organism specific

CTD

MGI

Cish2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cish2 Gene expression

Bgee

ArrayExpress

Genevestigator

Cish2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY