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Mouse Suppressor of cytokine signaling 5 (aa 1-536)

Cish5 Swiss Prot#

O54928

Cish5 Protein names

Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5)

Cish5 Gene names

Socs5 (Cish5)

Organism

Mouse

Cish5 Entry name

SOCS5_MOUSE

Cish5 Codon optimized cDNA(gene) Clone

Cish5 Cat #

RPA0692

Tag

Cish5 contains A 6x histidine tag

Cish5 Formulation

Liquid

Cish5 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Cish5 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Cish5 Protein

Cish5 Cat #

PA0692

Cish5 Source

recombinant

Cish5 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Cish5 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Cish5 Activity

N/A

Tag

Cish5 Contains A 6x histidine tag

Cish5 Formulation

Liquid

Cish5 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Cish5 family

-

Cish5 Subcellular locations

-

Cish5 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 is involved in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Cish5 Sequence

DDBJ

EMBL

GenBank

Cish5 3D structure

ModBase

Cish5 interaction

STRING

Cish5 Proteomic

PRIDE

Cish5 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Cish5 Organism specific

CTD

MGI

Cish5 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Cish5 Gene expression

Bgee

ArrayExpress

Genevestigator

Cish5 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY