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Mouse Multisynthetase complex auxiliary component p43 (aa 1-310)

Emap2 Swiss Prot#

P31230

Emap2 Protein names

Multisynthetase complex auxiliary component p43 [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)]

Emap2 Gene names

Scye1 (Emap2)

Organism

Mouse

Emap2 Entry name

AIMP1_MOUSE

Emap2 Codon optimized cDNA(gene) Clone

Emap2 Cat #

RPA0611

Tag

Emap2 contains A 6x histidine tag

Emap2 Formulation

Liquid

Emap2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Emap2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Emap2 Protein

Emap2 Cat #

PA0611

Emap2 Source

recombinant

Emap2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Emap2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Emap2 Activity

N/A

Tag

Emap2 Contains A 6x histidine tag

Emap2 Formulation

Liquid

Emap2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Emap2 family

-

Emap2 Subcellular locations

Nucleus. Cytoplasm > cytosol. Cytoplasmic vesicle > secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus.

Emap2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity).

Emap2 Sequence

DDBJ

EMBL

GenBank

Emap2 3D structure

ModBase

Emap2 interaction

STRING

Emap2 Proteomic

PRIDE

Emap2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Emap2 Organism specific

CTD

MGI

Emap2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Emap2 Gene expression

Bgee

ArrayExpress

Genevestigator

Emap2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY