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Mouse Leukocyte-associated immunoglobulin-like 1 (aa 22-263)

Lair1 Swiss Prot#

Q8BG84

Lair1 Protein names

Leukocyte-associated immunoglobulin-like 1-receptor 1 (LAIR-1) (mLAIR1) (CD antigen CD305)

Lair1 Gene names

Lair1

Organism

Mouse

Lair1 Entry name

LAIR1_MOUSE

Lair1 Codon optimized cDNA(gene) Clone

Lair1 Cat #

RPA0594

Tag

Lair1 contains A 6x histidine tag

Lair1 Formulation

Liquid

Lair1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Lair1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Lair1 Protein

Lair1 Cat #

PA0594

Lair1 Source

recombinant

Lair1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Lair1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Lair1 Activity

N/A

Tag

Lair1 Contains A 6x histidine tag

Lair1 Formulation

Liquid

Lair1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Lair1 family

-

Lair1 Subcellular locations

Cell membrane; Single-pass type I membrane protein.

Lair1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).

Lair1 Sequence

DDBJ

EMBL

GenBank

Lair1 3D structure

ModBase

Lair1 interaction

STRING

Lair1 Proteomic

PRIDE

Lair1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Lair1 Organism specific

CTD

MGI

Lair1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Lair1 Gene expression

Bgee

ArrayExpress

Genevestigator

Lair1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY