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Mouse ICOS ligand (aa 47-322)

B7h2 Swiss Prot#

Q9JHJ8

B7h2 Protein names

ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD antigen CD275)

B7h2 Gene names

Icoslg (B7h2) (B7rp1) (Icosl)

Organism

Mouse

B7h2 Entry name

ICOSL_MOUSE

B7h2 Codon optimized cDNA(gene) Clone

B7h2 Cat #

RPA0494

Tag

B7h2 contains A 6x histidine tag

B7h2 Formulation

Liquid

B7h2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

B7h2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant B7h2 Protein

B7h2 Cat #

PA0494

B7h2 Source

recombinant

B7h2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

B7h2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

B7h2 Activity

N/A

Tag

B7h2 Contains A 6x histidine tag

B7h2 Formulation

Liquid

B7h2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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B7h2 family

Immunoglobulin superfamily, BTN/MOG family

B7h2 Subcellular locations

Membrane; Single-pass type I membrane protein.

B7h2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.

B7h2 Sequence

DDBJ

EMBL

GenBank

B7h2 3D structure

ModBase

B7h2 interaction

STRING

B7h2 Proteomic

PRIDE

B7h2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

B7h2 Organism specific

CTD

MGI

B7h2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

B7h2 Gene expression

Bgee

ArrayExpress

Genevestigator

B7h2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY