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Human Stromal cell-derived factor 1 (a.a.22-114)

SDF1 Swiss Prot#

P48061

SDF1 Protein names

Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (Intercrine reduced in hepatomas) (IRH) (hIRH) [Cleaved into: SDF-1-beta(3-72) SDF-1-alpha(3-67)]

SDF1 Gene names

CXCL12 SDF1 SDF1A SDF1B

Organism

Human

SDF1 Entry name

SDF1_HUMAN

SDF1 Codon optimized cDNA(gene) Clone

SDF1 Cat #

RPA0336

Tag

SDF1 contains A 6x histidine tag

SDF1 Formulation

Liquid

SDF1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SDF1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SDF1 Protein

SDF1 Cat #

PA0336

SDF1 Source

recombinant

SDF1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SDF1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SDF1 Activity

N/A

Tag

SDF1 Contains A 6x histidine tag

SDF1 Formulation

Liquid

SDF1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SDF1 family

Intercrine alpha (chemokine CxC) family

SDF1 Subcellular locations

Secreted.

SDF1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase.

SDF1 Sequence

DDBJ

EMBL

GenBank

SDF1 3D structure

ModBase

SDF1 interaction

STRING

SDF1 Proteomic

PRIDE

SDF1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

SDF1 Organism specific

CTD

MGI

SDF1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SDF1 Gene expression

Bgee

ArrayExpress

Genevestigator

SDF1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY