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Human Tumor necrosis factor receptor superfamily 1A (a.a.24-93)

TNFAR Swiss Prot#

P19438

TNFAR Protein names

Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p60) (p55) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]

TNFAR Gene names

TNFRSF1A TNFAR TNFR1

Organism

Human

TNFAR Entry name

TNR1A_HUMAN

TNFAR Codon optimized cDNA(gene) Clone

TNFAR Cat #

RPA0313

Tag

TNFAR contains A 6x histidine tag

TNFAR Formulation

Liquid

TNFAR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TNFAR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TNFAR Protein

TNFAR Cat #

PA0313

TNFAR Source

recombinant

TNFAR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TNFAR Purity

>90%, as determined by SDS-PAGE under reducing conditions

TNFAR Activity

N/A

Tag

TNFAR Contains A 6x histidine tag

TNFAR Formulation

Liquid

TNFAR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TNFAR family

-

TNFAR Subcellular locations

Cell membrane; Single-pass type I membrane protein. Secreted.

TNFAR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

TNFAR Sequence

DDBJ

EMBL

GenBank

TNFAR 3D structure

ModBase

TNFAR interaction

STRING

TNFAR Proteomic

PRIDE

TNFAR Genome annotation

Ensembl

GeneID

KEGG

UCSC

TNFAR Organism specific

CTD

MGI

TNFAR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TNFAR Gene expression

Bgee

ArrayExpress

Genevestigator

TNFAR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY